POTENTIAL OF EXTRACELLULAR MICROVESICLES AS NEW COLORECTAL CANCER BIOMARKER

Abstract INTRODUCTION Colorectal cancer (CRC) is the third leading cause of death and fourth with highest incidence in world; early detection a key factor for patient´s prognosis. Microvesicles (MVs) are subcellular structures delimited by lipid bilayer intimately involved physiopathological processes such as cancer. Our objective to study potential microvesicles new biomarkers CRC. MATERIAL AND METHODS Blood was prospectively collected from 300 patients recruited during diagnostic colonoscopy. They were classified into control (no pathological findings), adenoma, high-grade adenoma or carcinoma groups. isolated serum selected cohort samples used MVs characterization CD174 surface antigen lateral flow immunoassay (LFI). RESULTS Mean age 62.79 (SD 7.662), being 90% asymptomatic at time recruitment. The mean size microparticles similar all groups, although larger variability observed group. concentration considerably lower CRC compared associated CD147 can be consistently detected on technique CONCLUSION preliminary results this project show that it possible use / prognostic markers. Likewise, feasible develop rapid tests using IFL technology could complement and/or replace current techniques.